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If not treated within 24 hours, Children with severe malaria frequently develop one or more of the following symptoms: severe anaemia, respiratory distress in relation to metabolic acidosis, or cerebral malaria.

In adults, multi-organ involvement is also frequent.

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Some population groups are at considerably higher risk of contracting malaria, and developing severe disease, than others.Pregnant women should avoid travelling to areas where malaria transmission occurs, and parents are advised not to take infants or young children to areas where there is risk of malaria transmission.Prior to their travel to malaria-endemic countries or regions, individuals should consult their national disease control centres, or other institutions offering travel advice, for information regarding the preventive measures that should be taken.All of the important vector species bite between dusk and dawn.